Pubblicazioni scientifiche (Siena)

•    De Simone M, Panetta D, Bramanti E, Giordano C, Salvatici MC, Gherardini L, Menciassi A, Burchielli S, Cinti C, Salvadori PA. Magnetically driven nanoparticles: 18 FDG-radiolabelling and positron emission tomography biodistribution study. Contrast Media Mol Imaging. 2016 Nov;11(6):561-571. doi: 10.1002/cmmi.1718

•    Pileri P, Campagnoli S, Grandi A, Parri M, De Camilli E, Song C, Ganfini L, Lacombe A, Naldi I, Sarmientos P, Cinti C, Jin B, Grandi G, Viale G, Terracciano L, Grifantini R. FAT1: a potential target for monoclonal antibody therapy in colon cancer. Br J Cancer. 2016 Jun 28;115(1):40-51. doi: 10.1038/bjc.2016.145.

•    Gherardini L, Sharma A, Capobianco E, Cinti C. Targeting Cancer with Epi-Drugs: A Precision Medicine Perspective. Curr Pharm Biotechnol. 2016;17(10):856-65.

•    El Baroudi M, Cinti C, Capobianco E. Immunomediated Pan-cancer Regulation Networks are Dominant Fingerprints After Treatment of Cell Lines with Demethylation. Cancer Inform. 2016 Apr 27;15:45-64. doi: 10.4137/CIN.S31809.

•    Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L, Carlomagno F. NCOA4 Deficiency Impairs Systemic Iron Homeostasis. Cell Rep. 2016 Jan 12. pii: S2211-1247(15)01506-5.

•    Malusa F, Taranta M, Zaki N, Cinti C, Capobianco E. Time-course gene profiling and networks in demethylated retinoblastoma cell line. Oncotarget. 2015 Sep 15;6(27):23688-707.

•    Valensin D, Cau Y, Calandro P, Vignaroli G, Dello Iacono L, Chiariello M, Mori M, Botta M. Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions. Bioorg Med Chem Lett. 2015 Dec 21. pii: S0960-894X(15)30379-6.

•    Camorani S, Crescenzi E, Colecchia D, Carpentieri A, Amoresano A, Fedele M, Chiariello M, Cerchia L. Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells. Oncotarget. 2015 Nov 10;6(35):37570-87.

•    Colecchia D, Rossi M, Sasdelli F, Sanzone S, Strambi A, Chiariello M. MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation. Autophagy. 2015 Oct 3;11(10):1790-802.

•    Morra F, Luise C, Merolla F, Poser I, Visconti R, Ilardi G, Paladino S, Inuzuka H, Guggino G, Monaco R, Colecchia D, Monaco G, Cerrato A, Chiariello M, Denning K, Claudio PP, Staibano S, Celetti A. FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC. Oncotarget. 2015 May 20;6(14):12697-709.

•    Gherardini L, Gennaro M, Pizzorusso T. Perilesional treatment with chondroitinase ABC and motor training promote functional recovery after stroke in rats. Cereb Cortex. 2015 Jan;25(1):202-12.

•    Naldi I, Taranta M, Gherardini L, Pelosi G, Viglione F, Grimaldi S, Pani L, Cinti C. Novel epigenetic target therapy for prostate cancer: a preclinical study. PLoS One. 2014 May 22;9(5):e98101.

•    El Baroudi M, La Sala D, Cinti C, Capobianco E. Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines. Theor Biol Med Model. 2014 May 7;11 Suppl 1:S8.

•    Capobianco E, Mora A, La Sala D, Roberti A, Zaki N, Badidi E, Taranta M, Cinti C. Separate and combined effects of DNMT and HDAC inhibitors in treating human multi-drug resistant osteosarcoma HosDXR150 cell line. PLoS One. 2014 Apr 22;9(4):e95596.

•    Mori M, Vignaroli G, Cau Y, Dinić J, Hill R, Rossi M, Colecchia D, Pešić M, Link W, Chiariello M, Ottmann C, Botta M. Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693. ChemMedChem. 2014 May;9(5):973-83.

•    Mora A, Taranta M, Zaki N, Badidi E, Cinti C, Capobianco E. Ensemble inference by integrative cancer networks. Front Genet. 2014 Mar 31;5:59.

•    Gherardini L, Ciuti G, Tognarelli S, Cinti C. Searching for the perfect wave: the effect of radiofrequency electromagnetic fields on cells. Int J Mol Sci. 2014 Mar 27;15(4):5366-87. Review.

•    Gherardini L, Bardi G, Gennaro M, Pizzorusso T. Novel siRNA delivery strategy: a new "strand" in CNS translational medicine? Cell Mol Life Sci. 2014 Jan;71(1):1-20.. Review.

•    Bardi G, Nunes A, Gherardini L, Bates K, Al-Jamal KT, Gaillard C, Prato M, Bianco A, Pizzorusso T, Kostarelos K. Functionalized carbon nanotubes in the brain: cellular internalization and neuroinflammatory responses. PLoS One. 2013 Nov 18;8(11):e80964.

•    Strambi A, Mori M, Rossi M, Colecchia D, Manetti F, Carlomagno F, Botta M, Chiariello M. Structure prediction and validation of the ERK8 kinase domain. PLoS One. 2013;8(1):e52011.

•    Albertazzi L, Gherardini L, Brondi M, Sulis Sato S, Bifone A, Pizzorusso T, Ratto GM, Bardi G. In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry. Mol Pharm. 2013 Jan 7;10(1):249-60.

•    Colecchia D, Strambi A, Sanzone S, Iavarone C, Rossi M, Dall'Armi C, Piccioni F, Verrotti di Pianella A, Chiariello M. MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins. Autophagy. 2012 Dec;8(12):1724-40.

•    Nunes A, Bussy C, Gherardini L, Meneghetti M, Herrero MA, Bianco A, Prato M, Pizzorusso T, Al-Jamal KT, Kostarelos K. In vivo degradation of functionalized carbon nanotubes after stereotactic administration in the brain cortex. Nanomedicine (Lond). 2012 Oct;7(10):1485-94.

•    J.C. Trivino Pardo, S. Grimaldi, M. Taranta, I. Naldi and C. Cinti. Microwave electromagnetic field regulates of gene expression in T-lymphoblastoid leukemia CCRF-CEM cell line exposed to 900 MHz. Electromagn Biol Med. 2012 Mar;31(1):1-18.

•    Lande C, Cecchettini A, Tedeschi L, Taranta M, Naldi I, Citti L, Trivella MG, Grimaldi S, Cinti C. Innovative erythrocyte-based carriers for gene delivery in porcine vascular smooth muscle cells: basis for local therapy to prevent restenosis. Cardiovasc Hematol Disord Drug Targets. 2012 Sep;12(1):68-75.

•    C. Cinti, M. Taranta. I. Naldi, S Grimaldi. Newly engineered magnetic erythrocytes for sustained and targeted delivery of anti-cancer therapeutic compounds. PLoS One. 2011 Feb 23;6(2):e17132.

•    C Cinti. In Cutting edge therapies for cancer in the 21st century: " Role of epigenetic alterations in the pathogenesis of cancer: recent clinical trial in epigenetic therapy". Edit by Claudio PP and Vogiatzi V. Bentham Science Publishers (2011).

•    Raffa V, Gherardini L, Vittorio O, Bardi G, Ziaei A, Pizzorusso T, Riggio C, Nitodas S, Karachalios T, Al-Jamal KT, Kostarelos K, Costa M, Cuschieri A. Carbon nanotube-mediated wireless cell permeabilization: drug and gene uptake. Nanomedicine (Lond). 2011 Dec;6(10):1709-18.

•    Leo L, Gherardini L, Barone V, De Fusco M, Pietrobon D, Pizzorusso T, Casari G. Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet. 2011 Jun;7(6):e1002129.

•    Al-Jamal KT, Gherardini L, Bardi G, Nunes A, Guo C, Bussy C, Herrero MA, Bianco A, Prato M, Kostarelos K, Pizzorusso T. Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing. Proc. Natl Acad Sci U S A. 2011 Jul 5;108(27):10952-7.

•    Rossi M, Colecchia D, Iavarone C, Strambi A, Piccioni F, Verrotti di Pianella A, Chiariello M. Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity. J Biol Chem. 2011 Mar 11;286(10):8507-22.


Collaborazioni:
Istituto di Neuroscienze (IN), CNR Pisa;
Istituto di Farmacologia Traslazionale (IFT), CNR Roma;
Istituto di Fisica Applicata (IFAC), CNR, Firenze;
Istituto di Biorobotica, Scuola Superiore Sant’Anna, Pisa;
Istituto Toscano Tumori (ITT), Firenze;
Istituto Superiore della Sanità, Roma;
Istituto Nazionale di Genetica Molecolare (INGM), Milano;
Joan C. Edwards School of Medicine, Marshall University, Huntington, USA;
Ovarian Cancer Research Center, School of Medicine, University of Pennsylvania, Philadelphia, USA;
Miller School of Medicine, University of Miami, Florida, USA;


Brevetti:
Inventors: Caterina Cinti, La Sala Dario.Title: Tests for detection of hot spot mutations and methylation of retinoblastoma -like 2 gene (RBL2) as diagnostic and prognostic markers of tumors. PCT/RO/101 patent application No. B30/0123;  International Pub. Date 6 Dic 2007; No WO 2007/137597 A1.

Inventor: Settimio Grimaldi, Antonella Lisi, Caterina Cinti, Title: “Erythro-magneto-virosomes as bioactive drug carriers”. Provisional USA  filed on 21 Dic. 2008.

 Inventor: Cinti Caterina, Settimio Grimaldi. Title: “Erythrocyte-based delivery system,method of preparation and uses thereof “International Pub. Date 24 June 2010, N. WO2010/070620.